VISUALIZATION OF DOPAMINE-D(3)-LIKE RECEPTORS IN HUMAN BRAIN WITH [125I]EPIDEPRIDE

被引：41

作者：

MURRAY, AM

RYOO, H

JOYCE, JN

机构：

[1] UNIV PENN, SCH MED,DEPT PSYCHIAT,CHEM NEUROANAT LAB, 111 CLIN RES BLDG,422 CURRIE BLVD, PHILADELPHIA, PA 19104 USA

[2] ROYAL COLL SURG IRELAND, DEPT CLIN PHARMACOL, DUBLIN 2, IRELAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 227卷 / 04期

关键词：

DOPAMINE-D(2) RECEPTORS; DOPAMINE-D(3) RECEPTORS; STRIATUM;

D O I：

10.1016/0922-4106(92)90164-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In sections of human brain containing the striatum (caudate, nucleus, putamen, nucleus accumbens) the competition for binding of [I-125]epidepride by compounds with differing selectivity for dopamine D2 and D3 receptors was examined. Domperidone showed higher affinity for D2-like than D3-like sites whereas 7-OH-DPAT (7-hydroxy-2-(N,N-di-n-propylamino)tetralin) and quinpirole demonstrated the reverse selectivity. The pattern of [I-125]epidepride binding in the presence of a high concentration of domperidone was negligible in the dorsal striatum but indicated islands of dense binding to D3-like receptors in the nucleus accumbens and ventral putamen.

引用

页码：443 / 445

页数：3

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