SUPEROXIDE RADICALS PLAY IMPORTANT ROLES IN THE PATHOGENESIS OF SPINAL-CORD INJURY

被引：46

作者：

TAOKA, Y

NARUO, M

KOYANAGI, E

URAKADO, M

INOUE, M

机构：

[1] Naruo Orthopedic Hospital, Kumamoto, 862

[2] Department of Biochemistry, Osaka City University, Medical School, Osaka

来源：

PARAPLEGIA | 1995年 / 33卷 / 08期

关键词：

SPINAL CORD INJURY; HYPOTENSION; ORTHOSTATIC HYPOTENSION; SUPEROXIDE RADICALS; EDRF (ENDOTHELIUM-DERIVED RELAXING FACTOR); EXPERIMENTAL SPINAL CORD INJURY;

D O I：

10.1038/sc.1995.98

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To investigate a possible role of supreoxide dismutase (SOD) in the pathogenesis of spinal cord injury (SCI), the change in the circulatory status in an experimental SCI model of rats was examined. The blood pressure (BP) of the SCI group decreased markedly by compression or head-up-tilt (60 degrees). The extent of the BP decrease was diminished by the administration of a long acting SOD (SM-SOD) prior to injury. Compression, tilting and the administration of SM-SOD increased the sensitivity of resistant arteries to acetylcholine. SM-SOD treated rats had a significantly lower mortality than was found in untreated rats. These findings indicate that superoxide radicals may contribute to the pathogenesis of spinal cord injury and orthostatic hypotension caused by SCI.

引用

页码：450 / 453

页数：4

共 28 条

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