QUINOLONES DO NOT INTERACT WITH NMDA RECEPTOR IN DISSOCIATED RAT HIPPOCAMPAL-NEURONS

被引：12

作者：

SHIRASAKI, T ^{[1
]}

HARATA, N ^{[1
]}

NAKAYE, T ^{[1
]}

AKAIKE, N ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROPHYSIOL,SENDAI,MIYAGI 980,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 562卷 / 02期

关键词：

RAT HIPPOCAMPAL NEURON; N-METHYL-D-ASPARTATE RESPONSE; QUINOLONE; FENBUFEN;

D O I：

10.1016/0006-8993(91)90645-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interaction of quinolone antimicrobials and fenbufen, anti-inflammatory agents, with the N-methyl-D-aspartate (NMDA) receptor was investigated in rat hippocampal neurons with the conventional patch-clamp technique. Simultaneous applications of quinolones and a metabolite of fenbufen had no effects on the glutamate- and NMDA-induced currents. The blocking effects of Mg2+ and MK-801 on NMDA responses were also unaffected. Therefore, the convulsive action induced by quinolones and fenbufen does not seem to involve the functional change of NMDA receptor.

引用

页码：344 / 346

页数：3

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