THE PULMONARY AND EXTRAPULMONARY EFFECTS OF INHALED BETA-AGONISTS IN PATIENTS WITH ASTHMA

被引：26

作者：

WINDOM, HH ^{[1
]}

BURGESS, CD ^{[1
]}

SIEBERS, RWL ^{[1
]}

PURDIE, G ^{[1
]}

PEARCE, N ^{[1
]}

CRANE, J ^{[1
]}

BEASLEY, R ^{[1
]}

机构：

[1] WELLINGTON SCH MED,DEPT MED,DEPT COMMUNITY HLTH,POB 7343,WELLINGTON S,WELLINGTON,NEW ZEALAND

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1990年 / 48卷 / 03期

关键词：

D O I：

10.1038/clpt.1990.152

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cardiovascular, respiratory, and hypokalemic effects of repeated inhalation of fenoterol, albuterol, and isoproterenol were compared in 12 subjects with stable asthma according to a double-blind, crossover design. Ipratropium bromide served as a control providing bronchodilatation without extrapulmonary effects. Subjecs inhaled the (3-agonists on an equal-weight basis (400 μg at 0, 30, 40, and 45 minutes. Measurements of heart rate, blood pressure, total electromechanical systole (measure of inotropic activity), preejection period, QTc interval, plasma potassium levels, and forced expiratory volume in 1 second were made 5 minutes after each dose and again at 60 and 75 minutes. There were no differences in the bronchodilating effect between the β-agonists. However, both fenoterol and isoproterenol resulted in greater positive inotropic stimulation than did albuterol, and fenoterol caused a greater fall in plasma potassium levels than did the other β-agonists. © 1990.

引用

页码：296 / 301

页数：6

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