ISOLATION AND STRUCTURE DETERMINATION OF INOSTAMYCIN, A NOVEL INHIBITOR OF PHOSPHATIDYLINOSITOL TURNOVER

被引：43

作者：

IMOTO, M ^{[1
]}

UMEZAWA, K ^{[1
]}

TAKAHASHI, Y ^{[1
]}

NAGANAWA, H ^{[1
]}

IITAKA, Y ^{[1
]}

NAKAMURA, H ^{[1
]}

KOIZUMI, Y ^{[1
]}

SASAKI, Y ^{[1
]}

HAMADA, M ^{[1
]}

SAWA, T ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1990年 / 53卷 / 04期

关键词：

D O I：

10.1021/np50070a008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the course of screening for phosphatidylinosicol turnover inhibitors, we found that a culture broth of a Streptomyces strain strongly inhibited the incorporation of inositol into phosphatidylinositol and its phosphates. The active principle was isolated from the broth through EtOAc extraction, cc, centrifugation partition chromatography, and crystallization. Spectroscopic and crystallographic analysis revealed that it has a novel polyether structure, and we named it inostamycin. Inostamycin inhibited phosphatidylinositol turnover with an IC50 of 0.5 μg/ml in cultured A431 cells. © 1990, American Chemical Society. All rights reserved.

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页码：825 / 829

页数：5

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