NEUROBIOLOGICAL STRUCTURE OF THE REVISED LIMIT-CYCLE RECIPROCAL INTERACTION-MODEL OF REM CYCLE CONTROL

被引：81

作者：

MCCARLEY, RW ^{[1
]}

MASSAQUOI, SG ^{[1
]}

机构：

[1] HARVARD MED SCH, DEPT PSYCHIAT, BROCKTON VET ADM MED CTR, BROCKTON, MA 02401 USA

来源：

JOURNAL OF SLEEP RESEARCH | 1992年 / 1卷 / 02期

关键词：

ACETYLCHOLINE; MODELS; NREM SLEEP; REM SLEEP; RHYTHMS;

D O I：

10.1111/j.1365-2869.1992.tb00026.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

New data bearing on the neurobiological basis of REM sleep and on mechanisms of EEG synchronization/desynchronization are presented. The revision of the limit cycle reciprocal interaction model (LCRIM) of REM cycle control incorporates new information on monoamine inhibition of mesopontine cholinergic neurons and of cholinergic mechanisms promoting REM sleep. New data also show cortical slow-wave activity is controlled by thalamocortical neurons' membrane potential level, which, in turn, is strongly controlled during sleep by brainstem cholinergic input arising from REM-on neurons. This new knowledge leads to a neurobiologically justified integration of the LCRIM and of the two-process model of sleep control.

引用

页码：132 / 137

页数：6

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