A FAMILIAL SYNDROME WITH CUTANEOUS MALIGNANT-MELANOMA AND CEREBRAL ASTROCYTOMA

被引：55

作者：

KAUFMAN, DK

KIMMEL, DW

PARISI, JE

MICHELS, VV

机构：

[1] MAYO CLIN & MAYO FDN, DEPT NEUROL, 200 1ST ST SW, ROCHESTER, MN 55905 USA

[2] MAYO CLIN & MAYO FDN, DEPT LAB MED & PATHOL, ROCHESTER, MN 55905 USA

[3] MAYO CLIN & MAYO FDN, DEPT MED GENET, ROCHESTER, MN 55905 USA

来源：

NEUROLOGY | 1993年 / 43卷 / 09期

关键词：

D O I：

10.1212/WNL.43.9.1728

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe a family in which cutaneous malignant melanoma or cerebral astrocytoma, or both, developed in eight members over three generations. Other malignancies also occurred with a lesser frequency. In two patients with both malignant melanoma and astrocytoma, the brain tumor followed the diagnosis of melanoma by a period of 2 and 10 years and was the primary cause of morbidity and mortality. The findings in this family may represent a newly described genetic disorder.

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页码：1728 / 1731

页数：4

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