FORMATION OF MEMBRANE CHANNELS BY CHRYSOSPERMINS - NEW PEPTAIBOL ANTIBIOTICS

被引：28

作者：

GRIGORIEV, P ^{[1
]}

SCHLEGEL, R ^{[1
]}

DORNBERGER, K ^{[1
]}

GRAFE, U ^{[1
]}

机构：

[1] HANS KNOLL INST NAT PROD RES,D-07745 JENA,GERMANY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1995年 / 1237卷 / 01期

关键词：

PEPTAIBOL; CHRYSOSPERMIN; LIPID BILAYER; CHANNEL FORMATION; VOLTAGE-DEPENDENT CONDUCTANCE;

D O I：

10.1016/0005-2736(95)00072-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The four homologous chrysospermins (Ia-d) are new 19 amino acid peptaibols which form cation selective ion channels in artificial lipid bilayer membranes. Conductance of channels formed by chrysospermins B (Ib) and D (Id) was twice as high (640 pS in 100 mM KCl) as found with chrysospermins A (Ia) and C (Ic). Single channel current traces were recorded for each of the four peptides even at very low (even zero) membrane voltages suggesting that non-gated channels are formed.

引用

页码：1 / 5

页数：5

共 21 条

[1] VOLTAGE-DEPENDENT CONDUCTANCE FOR ALAMETHICIN IN PHOSPHOLIPID-VESICLES - A TEST FOR THE MECHANISM OF GATING [J].