REDUCTION OF PERTECHNETATE-99 BY STANNOUS CHLORIDE .1. STOICHIOMETRY OF REACTION IN HCL, IN A CITRATE BUFFER AND IN A DTPA BUFFER

被引:84
作者
STEIGMAN, J
MEINKEN, G
RICHARDS, P
机构
[1] BROOKHAVEN NATL LAB,BLDG 801,UPTON,NY 11973
[2] DOWNSTATE MED CTR,DEPT RADIOL,BROOKLYN,NY 11203
来源
INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES | 1975年 / 26卷 / 10期
关键词
CHEMICAL REACTIONS - Reduction - Potentiometers;
D O I
10.1016/0020-708X(75)90078-2
中图分类号
TL [原子能技术]; O571 [原子核物理学];
学科分类号
0827 ; 082701 ;
摘要
The reduction of pertechnetate-99 by excess stannous chloride in several media was investigated as a possible model for radiopharmaceutical preparations which are based on the reduction of pertechnetate-99m by the same reagent. Polarographic and iodimetric techniques were used to analyze for unreacted stannous ion. It was found that pertechnetate is reduced to the plus 4 state in a citrate buffer at pH 7, to the plus 3 state in a DTPA buffer at pH 4, and possibly to the plus 4 state in HCl. The reaction in DTPA solution was found to be complete within several minutes. The reduction in the citrate buffer proceeded rapidly to the plus 5 state, and much more slowly to the plus 4 state. The implications of these rate studies for the radiopharmaceutical preparations are discussed. Data are presented in graphical and tabular form.
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页码:601 / 609
页数:9
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