BINDING OF DYE ANIONS TO PLASMA ALBUMIN AND LIPOPROTEINS

The capacity of human albumin for binding some common dye and indicator solutions[long dash]phenol red, methyl orange, sulphobrom-phthalein, bilirubin[long dash]is insufficient to account for maximum dye anion binding in normal human blood plasma. Discrepancies between plasma albumin assays by accepted separation methods and by certain dye-binding methods can be explained, at least in part, by the occurrence of lipoprotein-dye anion interactions.