CONTACT ALLERGY TO BRONOPOL

被引：24

作者：

FROSCH, PJ

WHITE, IR

RYCROFT, RJG

LAHTI, A

BURROWS, D

CAMARASA, JG

DUCOMBS, G

WILKINSON, JD

机构：

[1] ST JOHNS HOSP DIS SKIN,LONDON WC2H 7BJ,ENGLAND

[2] UNIV OULU,DEPT DERMATOL,SF-90100 OULU 10,FINLAND

[3] ROYAL VICTORIA HOSP,BELFAST BT12 6BA,NORTH IRELAND

[4] HOP PELLEGRIN,F-33076 BORDEAUX,FRANCE

[5] WYCOMBE GEN HOSP,HIGH WYCOMBE,BUCKS,ENGLAND

[6] HOSP NS MAR,BARCELONA,SPAIN

来源：

CONTACT DERMATITIS | 1990年 / 22卷 / 01期

关键词：

allergic contact dermatitis; Bronopol (2‐bromo‐2‐nitropropane‐1,3‐diol); cosmetics; medicaments; multicentre trial; patch testing; sensitization rate;

D O I：

10.1111/j.1600-0536.1990.tb01500.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A total of 8149 patients were patch tested with the preservative Bronopol in 7 European contact clinics. The Majority of patients (6507) were investigated in London. Reactivity was low, with a total of 10 irritant (0.12%) and 38 allergic reactions (0.47%). In only 17 cases (0.21%) was the patch test reaction to Bronopol considered to be of current or past clinical relevance. Concomitant sensitization to formaldehyde was present in about 1/3 of patients. Based on these figures, the present sensitization rate to Bronopol in Europe seems to be quite low, which may be related to its less frequent use as a preservative in cosmetics and medicaments in comparison to parabens or isothiazolinones. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：24 / 26

页数：3

共 10 条

[1]

FISCHER AA, 1980, CUTIS, V26, P136

[2] REACTIONS TO QUATERNIUM-15, BRONOPOL AND GERMALL-115 IN A STANDARD SERIES [J].