IMMUNOLOGICAL ASPECTS OF CARBAMAZEPINE TREATMENT IN EPILEPTIC PATIENTS

被引：36

作者：

PACIFICI, R ^{[1
]}

PARIS, L ^{[1
]}

DICARLO, S ^{[1
]}

PICHINI, S ^{[1
]}

ZUCCARO, P ^{[1
]}

机构：

[1] UNIV ROME,DEPT NEUROL,I-00100 ROME,ITALY

来源：

EPILEPSIA | 1991年 / 32卷 / 01期

关键词：

ANTICONVULSANTS; CARBAMAZEPINE; DRUG-INDUCED ABNORMALITIES; IMMUNOGLOBULINS; ACQUIRED IMMUNODEFICIENCY;

D O I：

10.1111/j.1528-1157.1991.tb05622.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Immune abnormalities have been found in epileptic patients receiving antiepileptic drugs (AEDs). Phenytoin (PHT) produces a decrease in serum IgA and IgM levels and a decrease in blastic transformation of circulating lymphocytes stimulated with phytohemoagglutinin (PHA). The effects of carbamazepine (CBZ) on the immune response are still conflicting. To elucidate the effects of CBZ on some immunologic parameters, serum concentrations of IgA, IgG, IgM, the phagocytosis and killing properties of polymorphonuclear leukocytes (PMNs), the cytotoxic activity of natural killer cells and the response of lymphocytes to mitogenic agents were studied. Forty healthy individuals and 39 epileptic patients treated with carbamazepine (CBZ) monotherapy (age range 18-40 years) entered the study. Student's t test was used to evaluate the data. CBZ had no effect on the serum immunoglobulin concentrations or on lymphocytic reactivity to phytohemoagglutinin (PHA) mitogen. CBZ produced a significant enhancement of phagocytosis and killing properties of PMNs and an increase in natural killer (NK) cell activity. Therefore, a negative effect of CBZ therapy on the immune system was not observed in this study.

引用

页码：122 / 127

页数：6

共 28 条

[1] IMMUNOLOGICAL ASPECTS OF EPILEPSY [J].