SYNTHESIS AND BIOLOGICAL STUDIES OF SOME NOVEL ANTIINFLAMMATORY ARYL-HYDROXY-AMINO-KETONES

被引：22

作者：

HADJIPAVLOULITINA, D

REKKA, E

HADJIPETROUKOUROUNAKIS, L

KOUROUNAKIS, P

机构：

[1] UNIV THESSALONIKI, SCH PHARM, DEPT PHARMACEUT CHEM, GR-54006 THESSALONIKI, GREECE

[2] UNIV THESSALONIKI, DEPT BIOL, DIV GENET DEV & MOLEC BIOL, GR-54006 THESSALONIKI, GREECE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 01期

关键词：

SYNTHESIS; CYCLIZATION OF 4-HYDROXY(OR AMINO)-ETHYLAMINO BUTYROPHENONES (OR THIENONES); INFLAMMATION; ANTI-NOCICEPTIVITY; LIPID PEROXIDATION;

D O I：

10.1016/0223-5234(91)90216-A

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of some 4-hydroxy-(or amino)-ethyl-amino butyrophenones or butyrothienones is described. The interconversion of these compounds to the corresponding 5-aryl-4-oxa-1-azabicyclo[3,3,0]octanes is presented. The title compounds demonstrated good antiinflammatory activity in the adjuvant induced disease model. They also possessed antinociceptive, immuno-modulating and antioxidant activity, properties which are probably involved in the mechanism of their action.

引用

页码：85 / 90

页数：6

共 29 条

[1] HYDROXYL RADICALS ARE NOT INVOLVED IN NADPH DEPENDENT MICROSOMAL LIPID-PEROXIDATION
BAST, A
STEEGHS, MHM
[J]. EXPERIENTIA, 1986, 42 (05): : 555 - 556
[2] SYNTHESIS AND PHARMACOLOGICAL ACTION OF SOME N-ALKYL MORPHOLINES AND THEIR SALTS
BECKETT, AH
HUNTER, WH
KOUROUNAKIS, P
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1968, S 20 : S218 - +
[3] OXIDATION AND MASS-SPECTRA OF 4,4-DIMETHYLOXAZOLIDINE-N-OXYL (DOXYL) DERIVATIVES OF KETONES
CHOU, S
NELSON, JA
SPENCER, TA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1974, 39 (16) : 2356 - 2361
[4] Gamma-chloropropyl-phenylketone
Conant, JB
Segur, JB
Kirner, WR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1924, 46 : 1882 - 1885
[5] MASS SPECTROMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS .64. A STUDY OF FRAGMENTATION PROCESSES OF SOME CYCLIC AMINES
DUFFIELD, AM
BUDZIKIE.H
WILLIAMS, DH
DJERASSI, C
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (04) : 810 - &
[6] Flohe L., 1985, OXIDATIVE STRESS, P403
[7] FLOWER RJ, 1985, PHARMACOL BASIS THER, P674
[8] THE INTERACTION BETWEEN LIPID-PEROXIDATION AND PROSTAGLANDIN SYNTHESIS IN RABBIT KIDNEY-MEDULLA SLICES
FUJIMOTO, Y
TANIOKA, H
KESHI, I
FUJITA, T
[J]. BIOCHEMICAL JOURNAL, 1983, 212 (01) : 167 - 171
[9] HADJIPETROUKOUROUNAKIS L, 1983, PHARM ACTA HELV, V58, P256
[10] THE OXYGEN FREE-RADICAL SYSTEM - POTENTIAL MEDIATOR OF MYOCARDIAL INJURY
HAMMOND, B
HESS, ML
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1985, 6 (01) : 215 - 220

← 1 2 3 →