CALIBRATION OF A PROMPT NEUTRON-ACTIVATION ANALYSIS FACILITY FOR THE MEASUREMENT OF TOTAL-BODY PROTEIN

被引：9

作者：

MACKIE, A ^{[1
]}

COWEN, S ^{[1
]}

HANNAN, J ^{[1
]}

机构：

[1] WESTERN GEN HOSP,DEPT MED PHYS & MED ENGN,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 1990年 / 35卷 / 05期

关键词：

D O I：

10.1088/0031-9155/35/5/002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Prompt neutron activation analysis with 252Cf has been used to measure total body protein. Since simultaneous irradiation and detection generated a high count rate at the detectors the nucleonic system was optimised to reduce distortions in the gamma -ray energy spectrum. Tissue-equivalent phantoms were used to calibrate the apparatus. A total of 53 studies was performed on 39 normal subjects. Ratios of total body protein to fat-free mass agreed well with those from other centres and with cadaver studies. Duplicate measurements of 14 subjects gave a coefficient of variation of +or-2.9% for a measurement of total body protein, which is close to that calculated from the known errors of the technique of +or-2.7%. The whole body dose equivalent was 0.17 mSv.

引用

页码：613 / 624

页数：12

共 27 条

[1] A PROMPT GAMMA INVIVO NEUTRON-ACTIVATION ANALYSIS FACILITY FOR MEASUREMENT OF TOTAL-BODY NITROGEN IN THE CRITICALLY ILL [J].

BEDDOE, AH ;

ZUIDMEER, H ;

HILL, GL .

PHYSICS IN MEDICINE AND BIOLOGY, 1984, 29 (04) :371-383

[2] EVALUATION OF AN INVIVO PROMPT GAMMA NEUTRON-ACTIVATION FACILITY FOR BODY-COMPOSITION STUDIES IN CRITICALLY ILL INTENSIVE-CARE PATIENTS - RESULTS ON 41 NORMALS [J].

BEDDOE, AH ;

STREAT, SJ ;

HILL, GL .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1984, 33 (03) :270-280

[3] DETERMINATION OF NITROGEN IN LIVING PATIENTS [J].

BIGGIN, HC ;

CHAMBERL.MJ ;

CHEN, NS ;

FREMLIN, JH ;

NOWOTNY, R ;

MORGAN, WD ;

ETTINGER, KV .

NATURE-NEW BIOLOGY, 1972, 236 (67) :187-&

[4] DENSITOMETRIC ANALYSIS OF BODY COMPOSITION REVISION OF SOME QUANTIATIVE ASSUMPTIONS [J].

BROZEK, J ;

ANDERSON, JT ;

KEYS, A ;

GRANDE, F .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1963, 110 (01) :113-&

[5] TOTAL-BODY NITROGEN AND ITS RELATION TO BODY POTASSIUM AND FAT-FREE MASS IN HEALTHY-SUBJECTS [J].

BURKINSHAW, L ;

MORGAN, DB ;

SILVERTON, NP ;

THOMAS, RD .

CLINICAL SCIENCE, 1981, 61 (04) :457-462

[6]

CHETTLE DR, 1982, J RADIOANAL CHEM, V7, P533

[7] CHANGES IN BODY CHEMICAL COMPOSITION WITH AGE MEASURED BY TOTAL-BODY NEUTRON-ACTIVATION [J].

COHN, SH ;

VASWANI, A ;

ZANZI, I ;

ALOIA, JF ;

ROGINSKY, MS ;

ELLIS, KJ .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1976, 25 (01) :85-96

[8] COMPARTMENTAL BODY-COMPOSITION BASED ON TOTAL-BODY NITROGEN, POTASSIUM, AND CALCIUM [J].

COHN, SH ;

VARTSKY, D ;

YASUMURA, S ;

SAWITSKY, A ;

ZANZI, I ;

VASWANI, A ;

ELLIS, KJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 239 (06) :E524-E530

[9]

FORBES RM, 1956, J BIOL CHEM, V223, P969

[10]

FORBES RM, 1953, J BIOL CHEM, V203, P359

← 1 2 3 →