THE WEAKNESS OF OLD-AGE IS NOT DUE TO FAILURE OF MUSCLE ACTIVATION

被引：88

作者：

PHILLIPS, SK ^{[1
]}

BRUCE, SA ^{[1
]}

NEWTON, D ^{[1
]}

WOLEDGE, RC ^{[1
]}

机构：

[1] ST HELENS HOSP,DEPT MED ELDERLY,HASTINGS,E SUSSEX,ENGLAND

来源：

JOURNALS OF GERONTOLOGY | 1992年 / 47卷 / 02期

关键词：

D O I：

10.1093/geronj/47.2.M45

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

Maximum voluntary force and cross-sectional area (MVF and CSA) of the human adductor pollicis muscle were compared in groups of young (19-55 years, mean = 28, n = 53) and elderly (74-90 years, mean = 80, n = 39) subjects, of both sexes. Despite the elderly subjects being in good health and active outdoors, they were considerably weaker than the young subjects, their MVF/CSA being 26 +/- 3% (mean +/- SEM) lower. It was found that both young and elderly subjects could fully activate their muscles. Therefore the muscle weakness of old age does not appear to be due to reduced activation and must be caused by another mechanism, possibly biochemical in nature.

引用

页码：M45 / M49

页数：5

共 36 条

[1]

ALNAQEEB MA, 1984, J ANAT, V139, P677

[2] REGULATION OF TENSION IN SKINNED MUSCLE-FIBERS - EFFECT OF CROSS-BRIDGE KINETICS ON APPARENT CA-2+ SENSITIVITY [J].

BRANDT, PW ;

COX, RN ;

KAWAI, M ;

ROBINSON, T .

JOURNAL OF GENERAL PHYSIOLOGY, 1982, 79 (06) :997-1016

[3] CONTRACTILE PROPERTIES OF SKELETAL-MUSCLES FROM YOUNG, ADULT AND AGED MICE [J].

BROOKS, SV ;

FAULKNER, JA .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 404 :71-82

[4] EFFECT OF SUBNUTRITION ON NORMALIZED MUSCLE FORCE AND RELAXATION RATE IN HUMAN-SUBJECTS USING VOLUNTARY CONTRACTIONS [J].

BRUCE, SA ;

NEWTON, D ;

WOLEDGE, RC .

CLINICAL SCIENCE, 1989, 76 (06) :637-641

[5] EFFECT OF AGE ON VOLUNTARY FORCE AND CROSS-SECTIONAL AREA OF HUMAN ADDUCTOR POLLICIS MUSCLE [J].

BRUCE, SA ;

NEWTON, D ;

WOLEDGE, RC .

QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1989, 74 (03) :359-362

[6]

BRUCE SA, 1990, IN PRESS 3RD P VIENN

[7]

BRUCE SA, 1985, J PHYSL, V372, P31

[8] THE RELATION OF GRIP STRENGTH AND GRIP-STRENGTH ENDURANCE TO AGE [J].

BURKE, WE ;

TUTTLE, WW ;

THOMPSON, CW ;

JANNEY, CD ;

WEBER, RJ .

JOURNAL OF APPLIED PHYSIOLOGY, 1953, 5 (10) :628-630

[9] AGE-DEPENDENT DECREASE OF CARNITINE CONTENT IN MUSCLE OF MICE AND HUMANS [J].

COSTELL, M ;

OCONNOR, JE ;

GRISOLIA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (03) :1135-1143

[10] EFFECTS OF FATIGUE AND ALTERED PH ON ISOMETRIC FORCE AND VELOCITY OF SHORTENING AT ZERO LOAD IN FROG-MUSCLE FIBERS [J].

EDMAN, KAP ;

MATTIAZZI, AR .

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 1981, 2 (03) :321-334

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