RETINOIC ACID RECEPTOR EXPRESSION DURING THE IN-VITRO DIFFERENTIATION OF HUMAN NEUROBLASTOMA

被引：27

作者：

LOVAT, PE

PEARSON, ADJ

MALCOLM, A

REDFERN, CPF

机构：

[1] UNIV NEWCASTLE,DEPT CHILD HLTH,NEWCASTLE TYNE NE2 4HH,ENGLAND

[2] UNIV NEWCASTLE,DEPT PATHOL,NEWCASTLE TYNE NE2 4HH,ENGLAND

[3] UNIV NEWCASTLE,DEPT MED,NEWCASTLE TYNE NE2 4HH,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1993年 / 162卷 / 1-2期

关键词：

NEUROBLASTOMA; RETINOIC ACID; DIFFERENTIATION; RETINOIC ACID RECEPTOR;

D O I：

10.1016/0304-3940(93)90572-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroblastoma cells differentiate in response to retinoic acid and cyclic AMP. We have examined the expression of retinoic acid receptors (RARs) in relation to neuroblastoma differentiation and show that short term exposure of SK N SH, SH SY 5Y AND GI LI N cells to physiological concentrations of retinoic acid results in induction of RAR-beta, particularly the lower transcript. Cyclic AMP has no effect on retinoic acid mediated induction and does not alter RAR expression patterns. These data are discussed in the light of evidence that retinoic acid and cyclic AMP act either on different control pathways or at different points within a common pathway.

引用

页码：109 / 113

页数：5

共 27 条

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