COMPLEMENT ALLOTYPES IN FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE

被引：3

作者：

PANEGYRES, PK

DAWKINS, RL

机构：

[1] WESTMEAD HOSP,DEPT NEUROL,WESTMEAD,NSW 2145,AUSTRALIA

[2] ROYAL PERTH HOSP,DEPT CLIN IMMUNOL,PERTH,WA 6000,AUSTRALIA

来源：

JOURNAL OF NEUROLOGY | 1991年 / 238卷 / 06期

关键词：

FAMILIAL ALZHEIMERS DISEASE; SPORADIC ALZHEIMERS DISEASE; COMPLEMENT ALLOTYPES;

D O I：

10.1007/BF00315331

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To resolve conflicting findings on the association of complement allotypes with Alzheimer's disease (AD) we have studied the C4 phenotypes in 33 sporadic cases and in one family with familial AD. We found no association with complement alleles in familial or sporadic AD, even though a familial case had absence of the C4 null allele (C4BQ0). Our data do not suggest a role for complement genes in the pathogenesis of AD. It also seems that the C4B2 allele cannot be used as a marker for AD as has been suggested by others.

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页码：325 / 326

页数：2

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