INHIBITION EFFECT OF AGGREGATION OF PHOSPHOLIPID-VESICLES BY INCORPORATION OF GLYCOLIPIDS

被引：9

作者：

TAKEOKA, S ^{[1
]}

SAKAI, H ^{[1
]}

OHNO, H ^{[1
]}

YOSHIMURA, K ^{[1
]}

TSUCHIDA, E ^{[1
]}

机构：

[1] WASEDA UNIV,DEPT POLYMER CHEM,TOKYO 169,JAPAN

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 1992年 / 152卷 / 02期

关键词：

D O I：

10.1016/0021-9797(92)90037-M

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Oligosaccharide fatty acid esters (glycolipids) [GkmCn; k, number of α-1,4-bound glucose unit (G) (k = 2, 5, 7); m, number of fatty acid (C) (m = 1, 2); and n, number of methylene unit (n = 12, 16, 22)] were synthesized. Aggregation of unilamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) below a gel-to-liquid crystalline phase transition temperature (43°C) were inhibited by incorporation of glycolipids into bilayer membrane and G51C16 was clarified to be the most effective structure. The complete inhibition by G51C16 could be achieved by the addition of 2 mol% of G51C16 to less than 0.5 wt% of DPPC liposomes at room temperature. This glycolipid also restricts the aggregation of liposomes induced by polyethyleneglycol or polysaccharide and improves the packing of lipids in the bilayer membrane. © 1992.

引用

页码：351 / 358

页数：8

共 34 条

[1] EFFECTS OF POLY(ETHYLENE GLYCOL) ON LIPOSOMES AND ERYTHROCYTES - PERMEABILITY CHANGES AND MEMBRANE-FUSION [J].