MULTICYCLE INFECTION OF HEPATITIS-C VIRUS IN CELL-CULTURE AND INHIBITION BY ALPHA-INTERFERON AND BETA-INTERFERON

被引：60

作者：

SHIMIZU, YK ^{[1
]}

YOSHIKURA, H ^{[1
]}

机构：

[1] NATL INST HLTH,DEPT VIRAL DIS & VACCINE CONTROL,TOKYO 208,JAPAN

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 12期

关键词：

D O I：

10.1128/JVI.68.12.8406-8408.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We previously reported that a clone of a human lymphocytic cell line, HPBMa clone 10-2, supports the genome replication of hepatitis C virus (HCV). In the present study, the multicycle transmission of HCV from infected cells to new cells was demonstrated by coculture with drug-resistant cells as recipients; i.e., the system was proved productive for infectious HCV. Inhibition of viral replication by alpha and beta interferons was observed.

引用

页码：8406 / 8408

页数：3

共 8 条

[1] RECOMBINANT INTERFERON-ALFA THERAPY FOR CHRONIC HEPATITIS-C - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

DIBISCEGLIE, AM ;

MARTIN, P ;

KASSIANIDES, C ;

LISKERMELMAN, M ;

MURRAY, L ;

WAGGONER, J ;

GOODMAN, Z ;

BANKS, SM ;

HOOFNAGLE, JH .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1506-1510

[2] EQUILIBRIUM CENTRIFUGATION STUDIES OF HEPATITIS-C VIRUS - EVIDENCE FOR CIRCULATING IMMUNE-COMPLEXES [J].

HIJIKATA, M ;

SHIMIZU, YK ;

KATO, H ;

IWAMOTO, A ;

SHIH, JW ;

ALTER, HJ ;

PURCELL, RH ;

YOSHIKURA, H .

JOURNAL OF VIROLOGY, 1993, 67 (04) :1953-1958

[3]

IKEDA H, 1988, GENE, V71, P19, DOI 10.1016/0378-1119(88)90073-X

[4] EVIDENCE FOR INVITRO REPLICATION OF HEPATITIS-C VIRUS GENOME IN A HUMAN T-CELL LINE [J].

SHIMIZU, YK ;

IWAMOTO, A ;

HIJIKATA, M ;

PURCELL, RH ;

YOSHIKURA, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5477-5481

[5] CORRELATION BETWEEN THE INFECTIVITY OF HEPATITIS-C VIRUS IN-VIVO AND ITS INFECTIVITY IN-VITRO [J].

SHIMIZU, YK ;

PURCELL, RH ;

YOSHIKURA, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :6037-6041

[6] NEUTRALIZING ANTIBODIES AGAINST HEPATITIS-C VIRUS AND THE EMERGENCE OF NEUTRALIZATION ESCAPE MUTANT VIRUSES [J].

SHIMIZU, YK ;

HIJIKATA, M ;

IWAMOTO, A ;

ALTER, HJ ;

PURCELL, RH ;

YOSHIKURA, H .

JOURNAL OF VIROLOGY, 1994, 68 (03) :1494-1500

[7]

SOUTHERN P J, 1982, Journal of Molecular and Applied Genetics, V1, P327

[8]

YOSHIKURA H, 1989, JPN J CANCER RES, V80, P1

← 1 →