STEREOSELECTIVE SYNTHESES OF (+)-TERCONAZOLE AND (-)-TERCONAZOLE

被引：6

作者：

CAMPS, P ^{[1
]}

FARRES, X ^{[1
]}

GARCIA, ML ^{[1
]}

MAULEON, D ^{[1
]}

CARGANICO, G ^{[1
]}

机构：

[1] LABS MENARINI SA, DEPT I & D, E-08912 BADALONA, SPAIN

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 09期

关键词：

D O I：

10.1016/0957-4166(95)00313-E

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The recently described cis-benzoates (2R,4R)- and (2S,4S)-2 were transformed into (+)- and (-)-terconazole, respectively, by reaction with 1H-1,2,4-triazole followed by hydrolysis to give alcohols (+)- and (-)-3 which were mesylated and reacted with phenol 5. The ee's of (+)-and(-)-terconazole determined by HPLC on the CSP Chiralcel OD-H were > 99%.

引用

页码：2365 / 2368

页数：4

共 4 条

[1] STEREOSELECTIVE SYNTHESES OF BOTH ENANTIOMERS OF KETOCONAZOLE FROM (R)-EPICHLOROHYDRIN AND (S)-EPICHLOROHYDRIN [J].