MULTIDETERMINANT ROLE OF CALCIUM IN HIPPOCAMPAL SYNAPTIC PLASTICITY

被引：90

作者：

TEYLER, TJ ^{[1
]}

CAVUS, I ^{[1
]}

COUSSENS, C ^{[1
]}

DISCENNA, P ^{[1
]}

GROVER, L ^{[1
]}

LEE, YP ^{[1
]}

LITTLE, Z ^{[1
]}

机构：

[1] MARSHALL UNIV,DEPT PHYSIOL,HUNTINGTON,WV

来源：

HIPPOCAMPUS | 1994年 / 4卷 / 06期

关键词：

LTP; LTD; NMDA; LONG-TERM POTENTIATION; CA1;

D O I：

10.1002/hipo.450040602

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hippocampal CA1 cells possess several varieties of long-lasting synaptic plasticity: two different forms of long-term potentiation (LTP) and at least one form of long-term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca2+ influx, all can be blocked by Ca2+ chelators, and all activate Ca2+-dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage-dependent differences in cytosolic Ca2+ concentration acting upon Ca2+ substrates of differing Ca2+ affinities and compartmentalization of the Ca2+ and its substrates. (C) 1994 Wiley-Liss, Inc.

引用

页码：623 / 634

页数：12

共 86 条

[51] PROTEIN KINASE-A INHIBITORS PREVENT THE MAINTENANCE OF HIPPOCAMPAL LONG-TERM POTENTIATION [J].