SCRATCHING THE SURFACE WITH THE PH DOMAIN

被引：59

作者：

FERGUSON, KM

LEMMON, MA

SIGLER, PB

SCHLESSINGER, J

机构：

[1] YALE UNIV,HOWARD HUGHES MED INST,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510

[2] NYU,MED CTR,DEPT PHARMACOL,NEW YORK,NY 10016

来源：

NATURE STRUCTURAL BIOLOGY | 1995年 / 2卷 / 09期

关键词：

D O I：

10.1038/nsb0995-715

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pleckstrin homology (PH) domains bind to membrane surfaces, and inositol phospholipids appear to form part of the binding sites. Recent structural studies provide a model for PH domain anchoring to inositol phospholipids that will open new avenues for functional investigation.

引用

页码：715 / 718

页数：4

共 26 条

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