BRONCHOALVEOLAR MAST-CELLS IN SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS - INCREASE IN NUMBERS AND ULTRASTRUCTURAL EVIDENCE OF DEGRANULATION

被引：6

作者：

ISHIDA, T

MATSUI, Y

MATSUMURA, Y

FUJIMORI, N

FURUTANI, M

机构：

[1] Department of Internal Medicine, Kurashiki Central Hospital, Kurashiki

[2] Department of Pathology, Kurashiki Central Hospital, Kurashiki

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 05期

关键词：

BRONCHOALVEOLAR LAVAGE; ULTRASTRUCTURE;

D O I：

10.2169/internalmedicine.34.357

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate the role of mast cells in the development of summer-type hypersensitivity pneumonitis (SHP), which is the most common type of hypersensitivity pneumonitis in Japan, bronchoalveolar lavage fluid (BALF) tells from 13 patients with this disease was studied by light and electron microscopy. The proportion and number of BALF mast cells recovered from SHP patients were significantly greater than those from patients with sarcoidosis and from control subjects. The BALF mast tells from the SHP patients showed various ultrastructural changes such as the transformation of granules, cytoplasmic vacuolation, and an increase of lipid droplets, These findings appeared to reflect activation and degranulation of bronchoalveolar mast cells, suggesting that mast cells play a role as inflammatory cells in the development of SHP.

引用

页码：357 / 363

页数：7

共 18 条

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