SELECTIVE HYDROLYSIS OF TRANSFER-RNA BY ETHYLENEDIAMINE BOUND TO A DNA OLIGOMER

被引：42

作者：

KOMIYAMA, M

INOKAWA, T

机构：

[1] Department of Chemistry and Biotechnology, Faculty of Engineering, University of Tokyo, Bunkyo-ku, Tokyo 113, Kongo

来源：

JOURNAL OF BIOCHEMISTRY | 1994年 / 116卷 / 04期

关键词：

ARTIFICIAL RIBONUCLEASE; ETHYLENEDIAMINE; HYDROLYSIS; TRANSFER-RNA;

D O I：

10.1093/oxfordjournals.jbchem.a124586

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A sequence-selective artificial ribonuclease was prepared by attaching ethylenediamine to the 5'-end of a DNA oligomer as the sequence-recognizing moiety. The hybrid, incorporating a 19-mer DNA which is complementary with the A44-A62 sequence of tRNA(Phe) hydrolyzed the tRNA selectively at the 3'-side of C63.

引用

页码：719 / 720

页数：2

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