SEVERE HEPATITIS CAUSED BY CYPROTERONE-ACETATE

被引：26

作者：

BLAKE, JC

SAWYERR, AM

DOOLEY, JS

SCHEUER, PJ

MCINTYRE, N

机构：

[1] ROYAL FREE HOSP,SCH MED,ACAD DEPT MED,LONDON NW3 2QG,ENGLAND

[2] ROYAL FREE HOSP,SCH MED,DEPT HISTOPATHOL,LONDON NW3 2QG,ENGLAND

来源：

GUT | 1990年 / 31卷 / 05期

关键词：

D O I：

10.1136/gut.31.5.556

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug. The association between the use of cyproterone acetate and liver abnormalities is poorly documented. This is the fourth published report of adverse hepatic reaction to cyproterone acetate and it substantiates other evidence that cyproterone acetate is potentially hepatotoxic. Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.

引用

页码：556 / 557

页数：2