A NOVEL SKELETAL DRUG DELIVERY SYSTEM FOR ANTIBACTERIAL DRUGS USING SELF-SETTING HYDROXYAPATITE CEMENT

被引：60

作者：

OTSUKA, M ^{[1
]}

MATSUDA, Y ^{[1
]}

YU, D ^{[1
]}

WONG, J ^{[1
]}

FOX, JL ^{[1
]}

HIGUCHI, WI ^{[1
]}

机构：

[1] UNIV UTAH, DEPT PHARMACEUT, SALT LAKE CITY, UT 84112 USA

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 12期

关键词：

DRUG DELIVERY SYSTEM; CEPHALEXIN; NORFLOXACIN; HYDROXYAPATITE; SELF-SETTING CEMENT; CONTROLLED RELEASE;

D O I：

10.1248/cpb.38.3500

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To solve the problem of delivering drugs to skeletal tissue at high enough local concentrations for desirable therapeutic effects, we report a novel approach using a self-setting hydroxyapatite cement, with cephalexin and norfloxacin as model drugs. After setting, the cement was transformed into hydroxyapatite with affinity for hard bone tissue. Continuous in-vitro drug release profiles from loaded cement pellets (0.9-4.8% by weight) in phosphate buffer at pH 7.4 and 37-degrees-C followed the Higuchi equation.

引用

页码：3500 / 3502

页数：3

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