USE OF BOP REAGENT FOR THE SUPPRESSION OF DIKETOPIPERAZINE FORMATION IN BOC/BZL SOLID-PHASE PEPTIDE-SYNTHESIS

被引：38

作者：

GAIRI, M ^{[1
]}

LLOYDWILLIAMS, P ^{[1
]}

ALBERICIO, F ^{[1
]}

GIRALT, E ^{[1
]}

机构：

[1] UNIV BARCELONA,DEPT QUIM ORGAN,MARTI & FRANQUES 1-11,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(00)88568-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

BOP coupling reagent suppresses the formation of diketopiperazines in the solid-phase coupling of the third amino acid to dipeptides when a nitro-benzylic "handle" is used to link the peptide to the resin. The amino function of the second amino acid may be deprotected with TFA and the coupling carried out without a prior neutralisation step. © 1990.

引用

页码：7363 / 7366

页数：4

共 17 条

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