NEW WATER-SOLUBLE PYROPHEOPHORBIDE A DERIVATIVES AS POSSIBLE AGENTS FOR PHOTODYNAMIC THERAPY OF CANCER

被引：15

作者：

ANDO, T

SUZUKI, Y

GEKA, R

IRIE, K

KOSHIMIZU, K

TAKEMURA, T

NAKAJIMA, S

SAKATA, I

机构：

[1] KYOTO UNIV,FAC AGR,DEPT FOOD SCI & TECHNOL,KYOTO 606,JAPAN

[2] HOKKAIDO UNIV,APPL ELECT RES INST,SAPPORO,HOKKAIDO 060,JAPAN

[3] ASAHIKAWA MED COLL,DIV SURG OPERAT,ASAHIKAWA 078,JAPAN

[4] TOYO HAKKA CO LTD,OKAYAMA 71903,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 38期

关键词：

PHOTODYNAMIC THERAPY (PDT); PHOTOSENSITIZER; PYROPHEOPHORBIDE A (PYROPPBA); TUMOR RETENTION; RAPID CLEARANCE;

D O I：

10.1016/S0040-4039(00)93440-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five new water-soluble pyroPPBa derivatives, whose vinyl groups at position 2 were converted into hydrophilic groups, were synthesized, and their in vivo tumor retention was measured by the N2-pulsed laser spectrofluorometry method. The results suggested that these derivatives were advantageous to reduce hyperphotosensitivity in skin, a major side effect of photodynamic therapy.

引用

页码：5107 / 5110

页数：4

共 12 条

[1] SYNTHESIS, PHYSICOCHEMICAL PROPERTIES AND PHOTOCYTOTOXICITY OF 5 NEW DELTA-SUBSTITUTED CHLORIN-E6 DERIVATIVES
ANDO, T
IRIE, K
KOSHIMIZU, K
TAKEMURA, T
NISHINO, H
IWASHIMA, A
NAKAJIMA, S
SAKATA, I
[J]. TETRAHEDRON, 1990, 46 (17) : 5921 - 5930
[2] BOCK G, 1989, PHOTOSENSITIZING COM, P146
[3] PHOTOSENSITIZERS - THERAPY AND DETECTION OF MALIGNANT-TUMORS
DOUGHERTY, TJ
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 45 (06) : 879 - 889
[4] GOMMER CJ, 1990, CANCER RES, V50, P3985
[5] PYRROLES AND RELATED COMPOUNDS .24. SEPARATION AND OXIDATIVE-DEGRADATION OF CHLOROPHYLL DERIVATIVES
KENNER, GW
MCCOMBIE, SW
SMITH, KM
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (21): : 2517 - 2523
[6] THE TUMOR-LOCALIZING PROPERTIES OF PORPHYRIN DERIVATIVES
NAKAJIMA, S
HAYASHI, H
OMOTE, Y
YAMAZAKI, Y
HIRATA, S
MAEDA, T
KUBO, Y
TAKEMURA, T
KAKIUCHI, Y
SHINDO, Y
KOSHIMIZU, K
SAKATA, I
[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1990, 7 (2-4) : 189 - 198
[7] NELSON JS, 1987, CANCER RES, V47, P4681
[8] ROEDER B, 1986, Studia Biophysica, V114, P171
[9] ROEDER B, 1986, Studia Biophysica, V114, P183
[10] Seely G. R., 1966, CHLOROPHYLLS, P67

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