ROLE OF ZINC IN INTERLEUKIN-2 (IL-2)-MEDIATED T-CELL ACTIVATION

被引：46

作者：

TANAKA, Y ^{[1
]}

SHIOZAWA, S ^{[1
]}

MORIMOTO, I ^{[1
]}

FUJITA, T ^{[1
]}

机构：

[1] KOBE UNIV,SCH MED,DEPT MED,DIV 3,KOBE 650,JAPAN

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 31卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1990.tb02805.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a serum‐free culture containing no zinc, zinc enhanced the proliferation of T cells in response to interleukin 2 (lL‐2), and also the in vitro production of lL‐2 by T cells. Although the lymphocyte proliferation was partially inhibited by anti‐IL‐2 antibodies, it was completely inhibited by anti‐IL‐2 receptor (CD25) antibodies. A Scatchard plot analysis showed that zinc induced the expression of high‐affinity receptors for IL‐2 on lymphocytes. The results indicated that zinc may be essentially required for IL‐2‐mediated T‐cell activation. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：547 / 552

页数：6

共 19 条

[1] SEVERE ZINC-DEFICIENCY IN HUMANS - ASSOCIATION WITH A REVERSIBLE LYMPHOCYTE-T DYSFUNCTION [J].