STUDY OF LOW-MOLECULAR-WEIGHT HEPARIN EFFECT ON THE RELATION BETWEEN ANTICOAGULANT ACTIVITY AND ANTITHROMBIN-III AFFINITY

被引：4

作者：

HAMANO, S ^{[1
]}

NISHIYAMA, M ^{[1
]}

KIKUCHI, S ^{[1
]}

KOMATSU, H ^{[1
]}

MIYATA, H ^{[1
]}

IKEDA, S ^{[1
]}

SAKURAGAWA, N ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,DEPT CLIN LAB MED,SUGITANI,TOYAMA 93001,JAPAN

来源：

THROMBOSIS RESEARCH | 1992年 / 66卷 / 04期

关键词：

LMW-HEPARIN; FR-860; UF-HEPARIN; ATIII AFFINITY; HC-II;

D O I：

10.1016/0049-3848(92)90280-N

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low molecular weight heparin (FR-860), and conventional unfractionated heparin (UF-heparin) were fractionated by rabbit antithrombin III (AT III)-Sepharose, and the effects of each affinity fraction on the coagulation and fibrinolytic activities were investigated. FR-860 was fractionated to no-affinity, low-affinity (LA). and high-affinity (HA) fractions, and UF-heparin to LA and HA fractions. The HA fractions showed higher activities regarding the prolongation of activated partial thromboplastin time, anti-factor Xa activity and antithrombin activity compared with those of LA. The HA and LA fractions exhibited the enhancement of heparin cofactor II (HC II) activity and flbrinolytic activity in a dose-dependent manner. These results suggest that the antithrombotic activity of FR-860 is exerted through AT III and other mechanism such as HC II -mediated system.

引用

页码：299 / 307

页数：9

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