MACROMOLECULAR SELF-ASSEMBLY OF DIKETOPIPERAZINE TETRAPEPTIDES

被引：47

作者：

BERGERON, RJ ^{[1
]}

PHANSTIEL, O ^{[1
]}

YAO, GW ^{[1
]}

MILSTEIN, S ^{[1
]}

WEIMAR, WR ^{[1
]}

机构：

[1] EMISPHERE TECHNOL INC,HAWTHORNE,NY 10532

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1994年 / 116卷 / 19期

关键词：

D O I：

10.1021/ja00098a007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Basic solutions of tetrapeptides derived from L-aspartic acid diketopiperazines are shown to form microcapsules when acidified to pH 2.4. An initial structure-activity study clearly demonstrates that a very delicate balance exists between the tetrapeptides' structure and their ability to self-assemble. Scanning electron micrographs confirm that microcapsules and not solid microspheres are formed.

引用

页码：8479 / 8484

页数：6

共 28 条

[1]

ANDERSON JM, 1974, BIOMED MATER S, P197

[2]

[Anonymous], 1987, ANGEW CHEM, V99, P707

[3] PEPTIDE SPONTANEOUSLY ASSEMBLES INTO MEMBRANE [J].