BIPARENTAL INHERITANCE OF CHROMOSOME-21 POLYMORPHIC MARKERS INDICATES THAT SOME ROBERTSONIAN TRANSLOCATIONS T(2121) OCCUR POSTZYGOTICALLY

被引：18

作者：

BLOUIN, JL

BINKERT, F

ANTONARAKIS, SE

机构：

[1] UNIV GENEVA,SCH MED,CMU,DIV MED GENET,CH-1211 GENEVA,SWITZERLAND

[2] JOHNS HOPKINS UNIV,SCH MED,CTR MED GENET,BALTIMORE,MD 21205

[3] UNIV ZURICH,SCH MED,INST MED GENET,ZURICH,SWITZERLAND

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1994年 / 49卷 / 03期

关键词：

DNA POLYMORPHISMS; CHROMOSOME; 21; ROBERTSONIAN TRANSLOCATION;

D O I：

10.1002/ajmg.1320490333

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Robertsonian translocations between acrocentric chromosomes are the most common structural chromosomal rearrangements in humans and many other organisms, and several mechanisms for their formation have been proposed. We have analyzed highly informative DNA polymorphisms in a family with a non-mosaic de novo Robertsonian translocation 21q;21q, to determine the parental origin of the two 21q arms of the rearranged chromosome. The genotypes indicated a biparental origin, i.e. one 21q was paternal and the other maternal. These results imply that in some cases the formation of the rob(21q;21q) occurs in the zygote or in the first few postzygotic mitotic divisions. (C) 1994 Wiley-Liss, Inc.

引用

页码：363 / 368

页数：6

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