IN-VIVO TREATMENT OF HEYMANN-NEPHRITIS USING A CYTOTOXIC PROTEIN-TOXIN CONJUGATE

被引：7

作者：

MISQUITH, S

SUROLIA, A

机构：

[1] INDIAN INST SCI,MOLEC BIOPHYS UNIT,BANGALORE 560012,KARNATAKA,INDIA

[2] INDIAN INST SCI,UGC CTR ADV STUDIES,BANGALORE 560012,KARNATAKA,INDIA

来源：

FEBS LETTERS | 1995年 / 373卷 / 02期

关键词：

HEYMANNS NEPHRITIS; GELONIN-GP330; CONJUGATE; CYTOTOXICITY;

D O I：

10.1016/0014-5793(95)01026-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study me investigated the possibility of treating Heymann's Nephritis (HN) by destroying antibody producing cells by targetting a toxin, gelonin - conjugated to gp330, the renal brush border antigen. HN was induced in rats by immunizing them with purified gp330. The gelonin-gp330 conjugate mas administered 12 days after the antigenic challenge. Serum was screened for circulating antibodies. Proteinurea was estimated. The gp330-gelonin conjugate-treated animals had a circulating antibody titre in the serum much lower than that of diseased (untreated) animals. Proteinurea seen in diseased animals was not observed in treated animals. This work suggests the possibility of using a toxin-antigen conjugate for immunomodulating antibody mediated autoimmune renal disease.

引用

页码：151 / 154

页数：4

共 26 条

[1]

BROWN RM, 1988, J IMMUNOL, V140, P893

[2] EXPERIMENTAL GLOMERULONEPHRITIS IN ISOLATED PERFUSED RAT-KIDNEY [J].