EFFECTS OF CAMP AND CGMP ELEVATING AGENTS ON HL-60 CELL-DIFFERENTIATION

被引：16

作者：

BANG, BE

ERICSEN, C

AARBAKKE, J

机构：

[1] Department of Pharmacology, Institute of Medical Biology, University of Tromsa, Tromsø, N-9037

来源：

PHARMACOLOGY & TOXICOLOGY | 1994年 / 75卷 / 02期

关键词：

D O I：

10.1111/j.1600-0773.1994.tb00331.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Previous studies have demonstrated low percentage of HL-60 cell differentiation with theophylline. The present study demonstrate that millimolar concentrations of the non-selective phosphodiesterase inhibitors theophylline, caffeine and isobutyl-methylxanthine all inhibit growth, induce substantial differentiation and elevation of both cAMP and cGMP in HL-60 cells. Selective inhibition of cAMP hydrolysis by Ro20-1724 was without effect. The guanylate cyclase stimulator sodium nitroprusside, which increased cGMP only poorly and also increased cAMP, produced growth inhibition but no differentiation. We put forward the hypothesis that elevation of both cAMP and cGMP above a critical level is necessary for significant cyclic nucleotide induced HL-60 cell differentiation.

引用

收藏

页码：108 / 112

页数：5

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