TOTAL SYNTHESIS OF (+)-DACTYLOL VIA A NOVEL [3+5]-ANNULATION APPROACH

被引：40

作者：

MOLANDER, GA

EASTWOOD, PR

机构：

[1] Department of Chemistry and Biochemistry, University of Colorado, Boulder

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 14期

关键词：

D O I：

10.1021/jo00119a038

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)-Dactylol (1) has been synthesized from the known (R)-3-methyl-2-methylenecyclopentanone (20) in six steps. The key step in the synthesis involves a regioselective and stereoselective [3 + 5] annulation to afford a tricyclic ether, which upon suitable functional group manipulation was opened to provide the natural product.

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页码：4559 / 4565

页数：7

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