CONCOMITANT CREUTZFELDT-JAKOB AND ALZHEIMER DISEASES

被引：39

作者：

POWERS, JM

LIU, Y

HAIR, LS

KASCSACK, RJ

LEWIS, LD

LEVY, LA

机构：

[1] COLUMBIA PRESBYTERIAN MED CTR,DEPT PATHOL,DIV NEUROPATHOL,NEW YORK,NY 10032

[2] NEW YORK STATE INST BASIC RES DEV DISABILITIES,IMMUNOL NEUROVIROL LAB,STATEN ISL,NY 10314

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROL,BRONX,NY 10461

[4] COLUMBIA PRESBYTERIAN MED CTR,DEPT NEUROL,NEW YORK,NY 10032

来源：

ACTA NEUROPATHOLOGICA | 1991年 / 83卷 / 01期

关键词：

CREUTZFELDT-JAKOB DISEASE; ALZHEIMERS DISEASE; AMYLOID; PROTEASE-RESISTANT PROTEIN (PRP); PANENCEPHALOPATHIC;

D O I：

10.1007/BF00294437

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identified by Western blot analysis of brain extracts.

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页码：95 / 98

页数：4

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