DIFFERENTIAL TIME COURSE OF PROTECTION BY MONOAMINE-OXIDASE INHIBITION AND UPTAKE INHIBITION AGAINST MPTP NEUROTOXICITY ON CENTRAL CATECHOLAMINE NEURONS IN MICE

被引：28

作者：

SUNDSTROM, E ^{[1
]}

JONSSON, G ^{[1
]}

机构：

[1] KAROLINSKA INST, DEPT HISTOL, BOX 60400, S-10401 STOCKHOLM 60, SWEDEN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1986年 / 122卷 / 02期

关键词：

D O I：

10.1016/0014-2999(86)90113-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pretreatment with the monoamine oxidase inhibitor pargyline or the catecholamine uptake blocker nomifensine both protected central catecholamine neurons against MPTP-induced neurotoxicity as monitored by analyzing catecholamine levels and [3H]mazindol binding. Post-treatment with the inhibitors showed that the administration of nomifensine could be delayed longer than that of pargyline in order to achieve a protective effect. The results are compatible with the view that the monamine oxidase-catalyzed conversion of MPTP to a toxic metabolite MPP+ occurs mainly extraneuronally. MPP+ is subsequently taken up and accumulated selectively in catecholamine neurons, initiating degeneration.

引用

页码：275 / 278

页数：4

共 10 条

[1]

CHIBA K, 1984, BIOCHEM BIOPH RES CO, V120, P478

[2] NEUROTOXICITY OF THE MEPERIDINE ANALOG N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].

HALLMAN, H ;

OLSON, L ;

JONSSON, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 97 (1-2) :133-136

[3] NEUROCHEMICAL AND HISTOCHEMICAL CHARACTERIZATION OF NEUROTOXIC EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].

HALLMAN, H ;

LANGE, J ;

OLSON, L ;

STROMBERG, I ;

JONSSON, G .

JOURNAL OF NEUROCHEMISTRY, 1985, 44 (01) :117-127

[4]

HEIKKILA RE, 1984, NATURE, V311, P467, DOI 10.1038/311467a0

[5] PARKINSONISM-INDUCING NEUROTOXIN, N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - UPTAKE OF THE METABOLITE N-METHYL-4-PHENYLPYRIDINE BY DOPAMINE NEURONS EXPLAINS SELECTIVE TOXICITY [J].

JAVITCH, JA ;

DAMATO, RJ ;

STRITTMATTER, SM ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (07) :2173-2177

[6]

JONSSON G, 1985, MPTP NEUROTOXIN PROD

[7] LIQUID-CHROMATOGRAPHIC ANALYSIS OF CATECHOLAMINES ROUTINE ASSAY FOR REGIONAL BRAIN MAPPING [J].

KELLER, R ;

OKE, A ;

MEFFORD, I ;

ADAMS, RN .

LIFE SCIENCES, 1976, 19 (07) :995-1003

[8] CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].

LANGSTON, JW ;

BALLARD, P ;

TETRUD, JW ;

IRWIN, I .

SCIENCE, 1983, 219 (4587) :979-980

[9] IMMUNO-CYTOCHEMICAL DEMONSTRATION OF MONOAMINE OXIDASE-B IN BRAIN ASTROCYTES AND SEROTONERGIC NEURONS [J].

LEVITT, P ;

PINTAR, JE ;

BREAKEFIELD, XO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (20) :6385-6389

[10] PHARMACOLOGICAL INTERFERENCE WITH THE NEUROTOXIC ACTION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) ON CENTRAL CATECHOLAMINE NEURONS IN THE MOUSE [J].

SUNDSTROM, E ;

JONSSON, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 110 (03) :293-299

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