EFFECT OF A NEW SYNTHETIC TRYPSIN-INHIBITOR ON TAUROCHOLATE-INDUCED ACUTE-PANCREATITIS IN RATS

被引:17
作者
SOBAJIMA, H [1 ]
HAYAKAWA, T [1 ]
KONDO, T [1 ]
SHIBATA, T [1 ]
KITAGAWA, M [1 ]
SAKAI, Y [1 ]
ISHIGURO, H [1 ]
TANIKAWA, M [1 ]
NAKAE, Y [1 ]
机构
[1] NAGOYA UNIV, SCH MED,DEPT INTERNAL MED 2,65 TSURUMA CHO, SHOWA KU, NAGOYA, AICHI 466, JAPAN
关键词
EXPERIMENTAL PANCREATITIS; PROTECTIVE AND THERAPEUTIC EFFECTS; SURVIVAL RATE; TRYPSIN;
D O I
10.1097/00006676-199303000-00016
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The effect of a novel synthetic trypsin inhibitor, 4-sulfamoylphenyl 4-guanidinobenzoate methanesulfonate (ONO-3307), on severe acute pancreatitis was studied by changing its timing, frequency, and dose in trypsin-taurocholate-induced acute experimental pancreatitis in rats. Rats were divided into four groups according to difference of ONO-3307 administration: group A, 2 mg/0.5 ml of ONO-3307 s.c. 1 h before and after induction of pancreatitis; group B, 2 mg/0.5 ml s.c. 1 and 3 h after; group C, 4 mg/1 ml s.c. 1 h before; group D, 4 mg/1 ml s.c. 1 h after. The survival rate at 24 h was significantly improved in group A (75% in A vs. 17% in control; p < 0.01) and in group B (57 vs. 29%; p < 0.05), but not in group C or D. Amylase and immunoreactive trypsin in serum and ascites of the treated were significantly lower than those of controls in both groups A and B. The survival rates were improved dose dependently when ONO-3307 was administered 1 h before and after induction of pancreatitis. ONO-3307 showed favorable effects on the initial stage of severe acute pancreatitis when given in divided doses to maintain the effective serum levels.
引用
收藏
页码:240 / 247
页数:8
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