EFFECT OF FORMULATION COMPONENTS ON DRUG-RELEASE FROM MULTIPARTICULATES

The effect of excipients on the release of drug from multiparticulates or pellets coated and uncoated prepared by the extrusion/spheronization and centrifugal processes is reviewed in this paper. A processing viewpoint has been taken because of the relationship between a rugged scaleable process and reliable excipients. Only aqueous coating dispersions have been reviewed because of their increasing usage due to environmental and cost reduction programs.