COMPARISON OF 3 COMMERCIAL PERFLUOROCARBON EMULSIONS AS HIGH-FIELD F-19 NMR PROBES OF OXYGEN-TENSION AND TEMPERATURE

被引：54

作者：

SHUKLA, HP ^{[1
]}

MASON, RP ^{[1
]}

WOESSNER, DE ^{[1
]}

ANTICH, PP ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT RADIOL,DALLAS,TX 75235

来源：

JOURNAL OF MAGNETIC RESONANCE SERIES B | 1995年 / 106卷 / 02期

关键词：

D O I：

10.1006/jmrb.1995.1023

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The increasing use of perfluorocarbons (PFCs) as probes of tissue oxygenation on the basis of the F-19 spin-lattice relaxation rate (R(1)) prompts comparison between several commercially available PFC blood-substitute emulsions, The relative sensitivities to both oxygen and temperature of the emulsions Oxypherol, Oxygent, and Fluosol at 7 T have been investigated, The linear response of R(1) with pO(2) was confirmed for each resonance in the range 4-50 degrees C, In general, R(1) is not a linear function of temperature, and we demonstrate this for perfluorotributylamine (FTBA) over an extended range of temperatures, 239-343 K. Theoretical R(1) values of FTBA were compared with experimental data by computer modeling of relaxation mechanisms, To further understand the structure-function relationships of PFCs, 2D COSY experiments were used for the assignment of resonances and as an aid in interpretation of relaxation mechanisms, Finally, the utility of Oxygent and Oxypherol for measuring tissue pO(2) in perfused rat hearts was compared before, during, and after eight minutes of global ischemia. (C) 1995 Academic Press, Inc.

引用

页码：131 / 141

页数：11

共 48 条

[1]

ABRAGAM A, 1961, PRINCIPLES NUCLEAR M

[2] PERFLUOROCARBON TEMPERATURE-MEASUREMENTS USING F-19 NMR [J].