DERIVATIZED CYCLODEXTRINS FOR NORMAL-PHASE LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS

被引：194

作者：

ARMSTRONG, DW

STALCUP, AM

HILTON, ML

DUNCAN, JD

FAULKNER, JR

CHANG, SC

机构：

[1] Department of Chemistry, University of Missouri—Rolla, Rolla

来源：

ANALYTICAL CHEMISTRY | 1990年 / 62卷 / 15期

关键词：

D O I：

10.1021/ac00214a014

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Several different derivatized β-cyclodextrins were synthesized and used as chiral stationary phases in normal-phase liquid chromatography. The multiply substituted derivatives were made with acetic anhydride, (R)-and (S)-1-(1-naphthyl)ethyl isocyanate, 2, 6-dimethylphenyl isocyanate, and p-toluoyl chloride. The first successful cyclodextrln-based, normal-phase separation of enantiomers was accomplished on these derivative phases. In contrast to chiral separations on the native β-cyclodextrin stationary phase, the enantiomeric separation mechanism on these new phases is not thought to be dependent on inclusion complexation. The similarities and differences between the derivatized cyclodextrin stationary phases and the cellulosic stationary phases are discussed. © 1990, American Chemical Society. All rights reserved.

引用

页码：1610 / 1615

页数：6

共 20 条

[1]

AMSTRONG DW, 1989, J CHROMATOGR, V462, P219

[2]

Armstrong D. W., 1985, US Pat., Patent No. [4 539 399, 4539399, 4,539,399]

[3] LIQUID-CHROMATOGRAPHIC SEPARATION OF DIASTEREOMERS AND STRUCTURAL ISOMERS ON CYCLODEXTRIN-BONDED PHASES [J].