SURFACE-PROPERTIES OF COPOLYMERS OF ALKYL METHACRYLATES WITH METHOXY (POLYETHYLENE OXIDE) METHACRYLATES AND THEIR APPLICATION AS PROTEIN-RESISTANT COATINGS

被引:199
作者
LEE, JH
KOPECKOVA, P
KOPECEK, J
ANDRADE, JD
机构
[1] UNIV UTAH,DEPT MAT SCI & ENGN,SALT LAKE CITY,UT 84112
[2] UNIV UTAH,DEPT BIOENGN,SALT LAKE CITY,UT 84112
关键词
alkyl methacrylates; Polyethylene oxide; protein removal; protein resistance;
D O I
10.1016/0142-9612(90)90058-X
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
New polymeric surfactants, copolymers of alkyl methacrylates with methoxy (polyethylene oxide) methacrylates, were synthesized and characterized by gel permeation chromatography. They were studied as possible means to produce polyethylene oxide-rich surfaces by a simple coating treatment on common Hydrophobie medical materials. They were further studied as cleaners for the removal of proteins preadsorfaed on hydrophobic surfaces. The surface properties of the copolymers such as the adsorption properties of the copolymer on a hydrophobic surface, low density polyethylene, the protein-resistant character of the prepared polyethylene oxide surfaces and the effectiveness of the copolymers for removal of proteins pre-adsorbed on the surface, were investigated by X-ray photoelectron spectroscopy and by using 125l-labelled copolymers and 125l-labelled proteins. The surface properties of the synthesized copolymers were compared with those of commercially available polyethylene oxide containing block copolymer surfactants. © 1990.
引用
收藏
页码:455 / 464
页数:10
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