PLASMA-LIPID ABNORMALITIES IN THE MINIATURE-POODLE WITH PROGRESSIVE ROD CONE DEGENERATION

被引：35

作者：

ANDERSON, RE ^{[1
]}

MAUDE, MB ^{[1
]}

ALVAREZ, RA ^{[1
]}

ACLAND, GM ^{[1
]}

AGUIRRE, GD ^{[1
]}

机构：

[1] UNIV PENN,SCH VET MED,PHILADELPHIA,PA 19104

来源：

EXPERIMENTAL EYE RESEARCH | 1991年 / 52卷 / 03期

关键词：

PRCD; RETINAL DEGENERATION; DOCOSAHEXAENOIC ACID; PLASMA LIPIDS; LIPIDS; RETINA; MINIATURE POODLE; DOG;

D O I：

10.1016/0014-4835(91)90100-S

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The miniature poodle with progressive rod-cone degeneration (prcd) is a model for human retinitis pigmentosa (RP). Since previous studies from several laboratories have shown abnormalities in plasma lipids in human RP, we examined the plasma lipids of prcd-affected animals. Fasting blood was drawn on three separate occasions from affected and control miniature poodles and on one occasion from normal Irish setters and those affected with a different inherited retinal degeneration (rod-cone dysplasia). Plasma phospholipids from prcd-affected animals had significantly lower levels of docosahexaenoic acid (22:6ω3) and cholesterol, compared to control miniature poodles. No differences were observed in plasma levels of phospholipids, vitamin E, or vitamin A, and no lipid differences were found between control and affected Irish setters. The ratios of 22:5ω3 to 22:6ω3 and of 22:4ω6 to 22:5ω6 were significantly elevated in prcd-affected poodles compared to controls. Since the conversion of 22:5ω3 to 22:6ω3 and of 22:4ω6 to 22:5ω6 is catalysed by a Δ4-desaturase, these results are consistent with a defect in desaturase activity in the prcd-affected poodle. © 1991.

引用

页码：349 / 355

页数：7

共 44 条

[1] RETINAL DEGENERATIONS IN THE DOG .3. ABNORMAL CYCLIC-NUCLEOTIDE METABOLISM IN ROD-CONE DYSPLASIA [J].