ACUTE GLUTAMATE TOXICITY AND ITS POTENTIATION BY SERUM-ALBUMIN ARE DETERMINED BY THE CA2+ CONCENTRATION

被引：15

作者：

EIMERL, S

SCHRAMM, M

机构：

[1] HEBREW UNIV JERUSALEM,DEPT BIOL CHEM,IL-91904 JERUSALEM,ISRAEL

[2] HEBREW UNIV JERUSALEM,OTTO LOEVI CTR NEUROBIOL,IL-91904 JERUSALEM,ISRAEL

来源：

NEUROSCIENCE LETTERS | 1991年 / 130卷 / 01期

关键词：

NMDA TOXICITY; CEREBELLAR GRANULE CELL; TOXICITY POTENTIATION IN CULTURED NEURONS;

D O I：

10.1016/0304-3940(91)90243-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two different processes, mediated by the N-methyl-D-aspartate receptor, appear to cause acute cell death in cultured cerebellar granule cells. A Ca2+-independent process takes place at zero and very low concentration of the added cation. Under these conditions, the known destabilization of excitable membranes at low extracellular Ca2+ probably plays a major role. A Ca2+-dependent process becomes dominant as its concentration is increased above 1.0 mM. The remarkable potentiation of glutamate toxicity by serum albumin is a calcium-dependent reaction.

引用

页码：125 / 127

页数：3

共 18 条

[1]

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