LONG-TERM CEREBRAL EFFECTS OF CNS CHEMOTHERAPY IN CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：21

作者：

BAKKE, SJ

FOSSEN, A

STORMMATHIESEN, I

LIE, SO

机构：

[1] UNIV OSLO,NATL HOSP,DEPT DIAGNOST RADIOL,NEURORADIOL SECT,N-0027 OSLO 1,NORWAY

[2] UNIV OSLO,NATL HOSP,DIV CHILD & ADOLESCENT PSYCHIAT,N-0027 OSLO 1,NORWAY

[3] UNIV OSLO,NATL HOSP,DEPT PEDIAT,N-0027 OSLO 1,NORWAY

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1993年 / 10卷 / 03期

关键词：

LEUKEMIA; CHEMOTHERAPY; MAGNETIC RESONANCE; NEUROPSYCHOLOGIC FUNCTIONS;

D O I：

10.3109/08880019309029495

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fifteen 7-16-year-old patients, treated in 1981-1984 for acute lymphoblastic leukemia (ALL) in first complete remission, were studied. As a central nervous system prophylaxis, all the children were treated with repeated methotrexate (MTX) instellations, but none were irradiated. The study protocol included magnetic resonance (MR) and a battery of neuropsychological tests. Small, punctate white-matter lesions were found by MR in eight children, probably minor vascular lesions. All the children were within normal intelligence range with a mean total WISC-R IQ of 109. Minor neuropsychologic problems were found in two patients, while one child showed a more extensive specific learning disorder in school.

引用

页码：267 / 270

页数：4

共 10 条

[1]

BERRY KE, 1989, VMI DEV TEST VISUALM

[2]

FAZEKAS F, 1991, AM J NEURORADIOL, V12, P915

[3]

KIRK JA, 1988, AM J PEDIAT HEMATOL, V10, P93

[4] CENTRAL-NERVOUS-SYSTEM DISEASE IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA - PROGNOSTIC FACTORS AND RESULTS OF TREATMENT [J].