IN-VIVO EVALUATION OF INDOMETHACIN/CYCLODEXTRIN COMPLEXES - GASTROINTESTINAL TOLERANCE AND DERMAL ANTIINFLAMMATORY ACTIVITY

Inclusion complexes of indomethacin in beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin were prepared and evaluated in vivo. With respect to the gastrointestinal tolerance assessed in the rat, it appears that the inclusion of indomethacin in these cyclodextrins results in a decrease in its irritation power, confirming that this undesirable effect has at least a local origin. With respect to the dermal anti-inflammatory activity assessed on healthy volunteers by the methyl nicotinate test, the results seem to demonstrate that inclusions in either of the cyclodextrins investigated have a higher activity than free indomethacin.