SYNTHETIC ANALOGS OF LOW-MOLECULAR-WEIGHT ACYL-POLYAMINE SPIDER TOXINS

被引：5

作者：

FIEDLER, WJ ^{[1
]}

GUGGISBERG, A ^{[1
]}

HESSE, M ^{[1
]}

机构：

[1] UNIV ZURICH, INST ORGAN CHEM, WINTERTHURERSTR 190, CH-8057 ZURICH, SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1993年 / 76卷 / 03期

关键词：

D O I：

10.1002/hlca.19930760304

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Low-molecular-weight spider and wasp toxins are selective inhibitors of glutamate receptors of the central nervous system and consist of a polyamine backbone and one or several carboxylic acids and/or amino acids linked by a peptide-like bond. The syntheses of twelve analogues of spider and wasp toxins are described (10a-c, 15a-c, 20a-c, 25a-c) having the general structure of acyl, arylacyl, or heteroarylacyl --> DL-alanyl --> omega-aminoacyl --> N1-spermidine, with variation in the acyl and the omega-aminoacyl part.

引用

页码：1167 / 1181

页数：15

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