THE SEPTUM AND AMYGDALA DIFFERENTIALLY MEDIATE THE ANXIOLYTIC EFFECTS OF BENZODIAZEPINES

被引：83

作者：

PESOLD, C ^{[1
]}

TREIT, D ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT PSYCHOL, EDMONTON T6G 2E9, AB, CANADA

来源：

BRAIN RESEARCH | 1994年 / 638卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

FEAR; ANXIETY; AMYGDALA; SEPTUM; MIDAZOLAM; RO; 15-1788; RECEPTOR;

D O I：

10.1016/0006-8993(94)90662-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinfusions of a benzodiazepine anxiolytic (midazolam) into the septum or the amygdala suppressed different fear reactions in two tests of rat ''anxiety''. Septal infusions increased open-arm activity in the plus-maze test and decreased burying behavior in the shock-probe test whereas amygdaloid infusions produced neither of these antianxiety effects. Amygdaloid infusions, however, dramatically impaired shock-probe avoidance, an antianxiety effect not produced by the septal infusions. Infusions of the benzodiazepine receptor antagonist Ro 15-1788 (flumazenil) blocked each of these specific, anti-fear effects of midazolam without producing intrinsic effects by itself. These results suggest that benzodiazepine receptor systems within the amygdala and the septum differentially mediate specific fear reactions.

引用

页码：295 / 301

页数：7

共 35 条

[1] BENZODIAZEPINE ANTAGONIST RO 15-1788 - NEUROLOGICAL AND BEHAVIORAL-EFFECTS [J].

BONETTI, EP ;

PIERI, L ;

CUMIN, R ;

SCHAFFNER, R ;

PIERI, M ;

GAMZU, ER ;

MULLER, RKM ;

HAEFELY, W .

PSYCHOPHARMACOLOGY, 1982, 78 (01) :8-18

[2] MULTIPLE BENZODIAZEPINE RECEPTORS - NO REASON FOR ANXIETY [J].

DOBLE, A ;

MARTIN, IL .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (02) :76-81

[3] MULTIPLE BENZODIAZEPINE RECEPTORS IN THE HUMAN BASAL GANGLIA - A DETAILED PHARMACOLOGICAL AND ANATOMICAL STUDY [J].

FAULL, RLM ;

VILLIGER, JW .

NEUROSCIENCE, 1988, 24 (02) :433-451

[4]

Gray J.A., 1982, NEUROPSYCHOLOGY ANXI

[5]

GREEN S, 1992, BEHAV PHARMACOL, V3, P261

[6]

GUIDOTTI A, 1990, ADV BIOCHEM PSYCHOPH, V46, P73

[7] NOVEL ANXIOLYTICS THAT ACT AS PARTIAL AGONISTS AT BENZODIAZEPINE RECEPTORS [J].

HAEFELY, W ;

MARTIN, JR ;

SCHOCH, P .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (11) :452-456

[8] BENZODIAZEPINE RECEPTORS STUDIED IN LIVING PRIMATES BY POSITRON EMISSION TOMOGRAPHY - ANTAGONIST INTERACTIONS [J].

HANTRAYE, P ;

BROUILLET, E ;

FUKUDA, H ;

CHAVOIX, C ;

GUIBERT, B ;

DODD, RH ;

PRENANT, C ;

CROUZEL, M ;

NAQUET, R ;

MAZIERE, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 153 (01) :25-32

[9]

HODGES H, 1987, PSYCHOPHARMACOLOGY, V92, P491

[10]

Hommer DW, 1987, PSYCHOPHARMACOLOGY 3, P977

← 1 2 3 4 →