EVALUATION OF 3RD-GENERATION ASSAYS FOR DETECTION OF ANTI-HEPATITIS-C VIRUS (HCV) ANTIBODIES AND COMPARISON WITH PRESENCE OF HCV RNA IN BLOOD-DONORS REACTIVE TO C100-3 ANTIGEN

被引：15

作者：

LAVANCHY, D

MAYERAT, C

MOREL, B

SCHNEIDER, P

ZUFFEREY, C

GONVERS, JJ

PECOUD, A

FREI, PC

机构：

[1] CTR TRANSFUS SANGUINE,LAUSANNE,SWITZERLAND

[2] POLICLIN MED UNIV,LAUSANNE,SWITZERLAND

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1994年 / 32卷 / 09期

关键词：

D O I：

10.1128/JCM.32.9.2272-2275.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We tested serum samples from blood donors by using first-, second-, and third-generation enzyme immunoassays or recombinant immunoblot assays. Second- and third-generation assays gave comparable results. Circulating hepatitis C virus RNA was found in a high proportion of reactive samples. A lack of reactivity or low-level reactivity predicted the absence of hepatitis C virus RNA in 100% of the cases.

引用

收藏

页码：2272 / 2275

页数：4

相关论文

共 24 条

[1] SERUM ALANINE AMINOTRANSFERASE OF DONORS IN RELATION TO THE RISK OF NON-A,NON-B HEPATITIS IN RECIPIENTS - THE TRANSFUSION-TRANSMITTED VIRUSES STUDY [J].

AACH, RD ;

SZMUNESS, W ;

MOSLEY, JW ;

HOLLINGER, FB ;

KAHN, RA ;

STEVENS, CE ;

EDWARDS, VM ;

WERCH, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 304 (17) :989-994

[2] INCIDENCE OF NON-A, NON-B HEPATITIS AFTER SCREENING BLOOD-DONORS FOR ANTIBODIES TO HEPATITIS-C VIRUS AND SURROGATE MARKERS [J].

BARRERA, JM ;

BRUGUERA, M ;

ERCILLA, G ;

SANCHEZTAPIAS, JM ;

GIL, MP ;

GIL, C ;

COSTA, J ;

GELABERT, A ;

RODES, J ;

CASTILLO, R .

ANNALS OF INTERNAL MEDICINE, 1991, 115 (08) :596-600

[3] TEMPORAL RELATIONSHIPS OF HEPATITIS-C VIRUS-RNA AND ANTIBODY-RESPONSES FOLLOWING EXPERIMENTAL-INFECTION OF CHIMPANZEES [J].

BEACH, MJ ;

MEEKS, EL ;

MIMMS, LT ;

VALLARI, D ;

DUCHARME, L ;

SPELBRING, J ;

TASKAR, S ;

SCHLEICHER, JB ;

KRAWCZYNSKI, K ;

BRADLEY, DW .

JOURNAL OF MEDICAL VIROLOGY, 1992, 36 (03) :226-237

[4]

BURCHKHARDT JJ, 1991, HAEMO, V3, P14

[5] EVALUATION OF 1ST-GENERATION AND 2ND-GENERATION RIBA KITS FOR DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS [J].

CHAUDHARY, RK ;

MACLEAN, C .

JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (10) :2329-2330

[6]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[7] RECOMBINANT IMMUNOBLOT ASSAY FOR HEPATITIS-C VIRUS-ANTIBODY AS PREDICTOR OF INFECTIVITY [J].

EBELING, F ;

NAUKKARINEN, R ;

LEIKOLA, J .

LANCET, 1990, 335 (8695) :982-983

[8] EVALUATION OF ANTIBODIES TO HEPATITIS-C VIRUS IN A STUDY OF TRANSFUSION-ASSOCIATED HEPATITIS [J].

ESTEBAN, JI ;

GONZALEZ, A ;

HERNANDEZ, JM ;

VILADOMIU, L ;

SANCHEZ, C ;

LOPEZTALAVERA, JC ;

LUCEA, D ;

MARTINVEGA, C ;

VIDAL, X ;

ESTEBAN, R ;

GUARDIA, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (16) :1107-1112

[9] ANTI-HCV IN POSTTRANSFUSION HEPATITIS - DEDUCTIONS FROM A PROSPECTIVE-STUDY [J].

FEINMAN, SV ;

BERRIS, B ;

HERST, R .

JOURNAL OF HEPATOLOGY, 1991, 12 (03) :377-381

[10] IMPROVED SERODIAGNOSIS OF HEPATITIS-C VIRUS-INFECTION WITH SYNTHETIC PEPTIDE ANTIGEN FROM CAPSID PROTEIN [J].

HOSEIN, B ;

FANG, CT ;

POPOVSKY, MA ;

YE, J ;

ZHANG, ML ;

WANG, CY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3647-3651