GENE-EXPRESSION OF ORNITHINE DECARBOXYLASE IN L1210 LEUKEMIA-CELLS EXPOSED TO DL-2-DIFLUOROMETHYLORNITHINE IN THE PRESENCE OF CADAVERINE

被引：17

作者：

ALHONENHONGISTO, L ^{[1
]}

SINERVIRTA, R ^{[1
]}

JANNE, OA ^{[1
]}

JANNE, J ^{[1
]}

机构：

[1] UNIV HELSINKI, DEPT BIOCHEM, SF-00170 HELSINKI 17, FINLAND

来源：

BIOCHEMICAL JOURNAL | 1985年 / 232卷 / 02期

关键词：

D O I：

10.1042/bj2320605

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cultured mouse L1210 leukaemia cells treated with DL-2-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase (EC 4.1.1.17), in the presence of micromolar concentrations of cadaverine, started to overproduce ornithine decarboxylase after an exposure of several weeks. The more than 60-fold excess of the enzyme protein in the drug-treated cells apparently resulted from a strikingly enhanced accumulation of mRNA for the enzyme associated with only a modest (about 2-fold) gene amplification.

引用

页码：605 / 607

页数：3

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